CD8+ Mycosis Fungoides in Peripheral Blood; A Rare Finding

Cutaneous T cell lymphomas are mature of lymphocyte presenting with skin lesions and/or systemic manifestations. Majority these cases show CD4+ phenotype and classified as Mycosis Fungoides (MF)/Sezary syndrome (SS) spectrum.
 Here we present a case 74-year-old male patient, having no known comorbid, presented in Dr. Ziauddin Hospital, Karachi OPD complains generalized lesions, itching for 2 years, weakness 4 months lymphadenopathy or visceromegaly. CBC showed absolute lymphocytosis eosinophilia. Some lymphocytes exhibited cerebriform nuclei. CT scan neck, chest abdomen bilateral enlarged superficial inguinal lymph nodes multiple axillary nodes. Skin biopsy was inconclusive. Immunophenotyping peripheral blood then performed which an aberrant population showing positivity CD3, CD8, CD2, CD25 negative CD4, CD45, CD5, CD30, CD56 variable expression CD7. Case finalized CD8+ involvement.
 These findings very rare highlight the importance integrated approach to clinical course, morphological other ancillary tests be used correlation each other. also diversity malignancies terms immunophenotype.